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Electrocardiographic criteria for tricyclic antidepressant cardiotoxicity. In substituted sancycline compounds of the invention, R 4′ and R 4″ are each alkyl (eg, lower alkyl, eg, methyl); X is CR 6R 6′; and R 6, R 6′ and R 5 are each, generally, hydrogen.
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An endogenous gene can be operatively linked to a tet operator sequence(s) by homologous recombination between a recombination vector comprising a TRE and sequences of the endogeneous gene.
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