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Após a sua comercialização também foram observados: (1) eventos cardiovasculares (a maioria desses eventos ocorreu durante ou logo após o ato sexual e em portadores de outros fatores de risco – predisposição – para doenças cardiovasculares), infarto do miocárdio (entupimento das artérias do coração), morte cardíaca repentina (parada cardíaca repentina), arritmia ventricular (alteração do ritmo do coração), hemorragia cerebrovascular (derrame cerebral), ataque isquêmico transitório (disfunção neurológica passageira decorrente da redução da quantidade de sangue no cérebro), hipotensão (redução da pressão arterial), taquicardia (aumento do ritmo cardíaco); (2) outros: Neuropatia óptica isquêmica anterior não-arterítica (lesão do nervo óptico por redução da quantidade de sangue), diminuição ou perda repentina da audição, reação de hipersensibilidade (alergia), incluindo rash cutâneo (vermelhidão da pele), convulsão (ataque epiléptico), convulsão recorrente, taquicardia (aceleração dos batimentos do coração), hipotensão (pressão baixa), síncope (desmaio), epistaxe (sangramento nasal), vômito, dor ocular, olhos vermelhos, ereção prolongada e/ou priapismo (ereção persistente e dolorosa do pênis). The authors cite a 2005 University of Toronto study of the brain scans of 24 subjects who were administered amphetamine.